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. Author manuscript; available in PMC: 2019 Dec 25.
Published in final edited form as: Chem Biol Interact. 2018 Oct 1;296:117–123. doi: 10.1016/j.cbi.2018.09.020

Figure 1.

Figure 1.

(A) Dose-dependent hepatoprotective effects of Phl (0.20 – 2.40 mmol/kg) administered by intraperitoneal injection 20 minutes prior to oral APAP (500 mg/kg) overdose. (B) Dose-dependent toxicity (lethality) of Phl (0.20 – 2.40 mmol/kg) administered alone by intraperitoneal injection. Kaplan-Meier survival curves illustrate the cumulative percent daily lethality in the APAP alone and APAP/Phl groups (n= 15 mice/group). Joining lines indicate statistically significant differences in treatment groups at *p<0.05, *p<0.01 and *** p<0.001 levels of significance.