Figure 1. Schematic illustrating the cross-tissue and cross-model comparisons conducted to identify common and unique molecular alterations across SCA1 affected tissues.

Transcriptomics data from Atxn1^154Q/2Q KI inferior olive and cerebellum were first analyzed individually (1-2) before comparing the two tissues (3). Using the ATXN1-82Q Tg inferior olive, comparison of the Atxn1^154Q/2Q KI and ATXN1-82Q Tg inferior olive was assessed (4) before evaluating similarities and differences between ATXN1-82Q Tg affected tissues (5). Finally, a cerebellar cross-model comparison was conducted (6).