Table 2. Enrichment for Cic binding site DNA motifs in down- and up-regulated 12 week old Atxn1^154Q/2Q inferior olive and cerebellum.

Cic DNA motif	Brain region	Motif occurrence	Down-Regulated	Shuffled	p-value	q-value
TGAATGAA	Inferior Olive	Present	31	19	0.090	0.095
		Absent	129	141
	Cerebellum	Present	126	57	5.6e-8	2.9e-7
		Absent	604	673
TGAATGGA	Inferior Olive	Present	35	25	0.197	0.148
		Absent	125	135
	Cerebellum	Present	157	104	3.7e-4	9.7e-4
		Absent	573	626
Cic DNA Motif	Brain Region	Motif Occurrence	Up-Regulated	Shuffled	p-value	q-value
TGAATGAA	Inferior Olive	Present	10	4	0.143	0.125
		Absent	34	40
	Cerebellum	Present	32	19	0.073	0.095
		Absent	181	194
TGAATGGA	Inferior Olive	Present	13	2	0.003	0.005
		Absent	31	42
	Cerebellum	Present	38	29	0.287	0.188
		Absent	175	184

FDR p-value calculated using the two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli (Q 5%).