Table 3. Enrichment for Cic binding site DNA motifs in down- and up-regulated genes from 12 week old ATXN1-82Q Tg inferior olive and cerebellum.

Cic DNA motif	Brain region	Motif occurrence	Down-Regulated	Shuffled	p-value	q-value
TGAATGAA	Inferior Olive	Present	12	1	0.002	0.002
		Absent	56	67
	Cerebellum	Present	90	48	1.9e-4	4.0e-4
		Absent	510	552
TGAATGGA	Inferior Olive	Present	19	13	0.312	0.187
		Absent	49	55
	Cerebellum	Present	110	86	0.073	0.061
		Absent	490	514
Cic DNA Motif	Brain Region	Motif Occurrence	Up-Regulated	Shuffled	p-value	q-value
TGAATGAA	Inferior Olive	Present	10	7	0.606	0.318
		Absent	60	63
	Cerebellum	Present	97	51	4.9e-5	2.1e-4
		Absent	366	412
TGAATGGA	Inferior Olive	Present	15	7	0.103	0.072
		Absent	55	63
	Cerebellum	Present	96	59	0.002	0.002
		Absent	367	404

FDR p-value calculated using the two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli (Q 5%).