Table 1.
Participant Demographics, By Site
| Control | 22q11DS | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Site | N | N (%) femalea | Mean ageb | Age SD | N (%) right handedc | IQ (SD)d | N | N (%) female | Mean age | Age SD | N (%) right handed | IQ (SD) |
| Cardiff | 11 | 6 (54.5) | 14.5 | 1.6 | 6 (55%) | 106.7 (7.5) | 15 | 8 (53.3) | 15.1 | 2.9 | 12 (67%) | 77.4 (19.1) |
| London IoP | 25 | 15 (60) | 19.6 | 6 | 24 (96%) | 115.9 (10.3) | 37 | 17 (45.9) | 16.6 | 7.2 | 28 (75.7%) | 84.7 (12.9) |
| Maastricht + | 45 | 15 (33.3) | 29.3 | 9.6 | 6 (85.7%) | 106.4 (15.4) | 27 | 13 (48.1) | 29.2 | 6.7 | 13 (76.5%) | 74.5 (11.3) |
| Newcastle | 26 | 14 (53.8) | 16.8 | 3.3 | 19 (79%) | 108.7 (15.7) | 19 | 12 (63.2) | 17.2 | 2.9 | 17 (89.5%) | 73.7 (13.6) |
| U Penn | 48 | 20 (41.7) | 17.5 | 3.2 | 39 (81.3%) | NA++ | 49 | 19 (38.8) | 17.3 | 3.2 | 38 (86.4%) | 76.3 (18.6) |
| SUNY Upstate | 20 | 8 (40) | 20.5 | 1.2 | 17 (85%) | 105.2 (14.1) | 54 | 24 (44.4) | 20.7 | 2.3 | 37 (78.7%) | 73.7 (11.3) |
| Toronto1 | 12 | 4 (33.3) | 42.4 | 8.7 | 9 (75%) | — | 15 | 7 (46.7) | 41.5 | 7.6 | 12 (80%) | 72.5 (10.9) |
| Toronto2 | 0 | NA | NA | NA | — | — | 35 | 22 (62.9) | 27.8 | 10.2 | 28 (80%) | 72.2 (10.1) |
| UCDavis1 | 38 | 19 (50) | 10.4 | 2.5 | 32 (86%) | 114.4 (11.0) | 40 | 17 (42.5) | 10.7 | 2.1 | 29 (72.5%) | 72.7(13.3) |
| UCDavis2 | 48 | 23 (47.9) | 10.8 | 2.4 | 45 (93.8%) | 113.7 (14.6) | 64 | 30 (46.9) | 11.3 | 2.5 | 53 (82.8%) | 75.5 (13.2) |
| UCLA1 | 23 | 16 (69/6) | 14.3 | 5.7 | 22 (95.7%) | 118.1 (20.5) | 28 | 14 (50) | 14.4 | 6.7 | 22 (84.6%) | 80.7 (14.6) |
| UCLA2 | 19 | 5 (26.3) | 13.3 | 3.6 | 13 (72.2%) | 104.7 (17.8) | 38 | 21 (55.3) | 15.8 | 7.9 | 28 (73%) | 77.6 (12.2) |
| Utrecht | 0 | NA | NA | NA | — | — | 53 | 38 (71.7) | 17.6 | 4.2 | 38 (74.5%) | 69.7 (8.5) |
| Total | 315 | 145 (46) | 18 | 9.2 | 232 (85%) | 111.6** (15.1) | 474 | 242 (51.1) | 18.2 | 8.6 | 333 (74.7%) | 75.2 (13.2) |
+ Maastricht- IQ missing for 13 controls [other controls received Dutch National Adult Reading Test (NART)]; handedness based on 7 controls and 17 22q11DS cases; + + At UPenn, controls received Penn-CNB and WRAT as proxy measures of IQ (Supplementary Table S1)
aΧ2 = 1.9, p = .17; Cramer’s V = .049; b. F = .094; p = .76; d = .00; c. Χ2 = 11.25; p = .004; Cramer’s V = 0.13; d. F = 1052.43; p < .001; d = 2.5