Figure 2. HEM/CLP enhances HVEM expression on Epcam+, CD11c+ and B220+ cells in the lung.
At 24 hours after iALI, HVEM expression in lung cells increased significantly compared to sham surgery mice. HVEM siRNA treatment by I.T. injection down-regulated HVEM expression only in Epcam+ (A), CD11c+ (B) and B220+ (C) cells, but no changes in other cell types (D–G). Mean ± SEM, n=4–6 mice per group; *P<0.05 vs. PBS treated iALI (Hem/CLP) group as compared to the Sham/Sham (Sh/Sh) group, ANOVA.