Table 1. List of KEGG pathways that were enriched for DEGs identified in the offspring and grandoffspring.
DEGs identified as having a q < 0.45 in the offspring, and q < 0.2 in the grandoffspring were used to conduct functional annotation with David 6.8 was to determine the KEGG pathways associated with DEGs identified in the amygdala of offspring and grandoffspring individually, and the common DEGs in the offspring and grandoffspring.
| Offspring DEGs | ||
|---|---|---|
| KEGG Pathway | # of genes | p value |
| Ribosome | 49 | 3.90E-22 |
| Oxidative phosphorylation | 39 | 1.30E-14 |
| Parkinson’s disease | 39 | 1.50E-13 |
| Huntington’s disease | 43 | 6.20E-12 |
| Alzheimer’s disease | 39 | 4.50E-11 |
| Non-alcoholic fatty liver disease (NAFLD) | 33 | 6.30E-09 |
| Cardiac muscle contraction | 17 | 3.20E-05 |
| Axon guidance | 19 | 1.90E-03 |
| Morphine addiction | 15 | 2.90E-03 |
| Retrograde endocannabinoid signaling | 16 | 2.90E-03 |
| Grandoffspring DEGs | ||
| KEGG Pathway | # of genes | p value |
| Notch signaling pathway | 17 | 2.10E-06 |
| Protein export | 9 | 2.70E-03 |
| Ubiquitin mediated proteolysis | 24 | 2.70E-03 |
| Protein processing in endoplasmic reticulum | 27 | 2.80E-03 |
| Proteasome | 11 | 4.70E-03 |
| Spliceosome | 22 | 5.50E-03 |
| Endocytosis | 38 | 6.20E-03 |
| Focal adhesion | 30 | 7.20E-03 |
| Signaling pathways regulating pluripotency of stem cells | 22 | 8.30E-03 |
| Common Offspring and Grandoffspring DEGs | ||
| KEGG Pathway | # of genes | p value |
| ECM-receptor interaction | 6 | 2.90E-04 |