Figure 2.

Scatterplots of associations between genetic smoking signature and (A) tumor mutational load (log-transformed), (B) cytolytic score (log-transformed), (C) enrichment in interferon-γ signaling, and (D) overall immune infiltration, as measured by ESTIMATE Immune Score. Correlations for head and neck squamous cell carcinoma (HNSC; all sites), HNSC (larynx only), and lung squamous cell carcinoma were determined using Spearman correlation (ρ with P value) and curve fitting with LOESS regression. CYT = cytolytic; H&N = head and neck; SCC = squamous cell carcinoma.