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. 2018 Apr 11;110(12):1386–1392. doi: 10.1093/jnci/djy060

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Figure 3. — A) Heatmap of Ingenuity Pathway Analysis–defined canonical pathways altered in either head and neck squamous cell carcinoma (HNSC) or lung squamous cell carcinoma (LUSC), showing an immunosuppressive phenotype in smoking-high HNSC, with the color legend representing directional z-score (Supplementary Tables 8 and 9, available online). B) Dot plot of results from Gene Set Enrichment Analysis (GSEA) of pathways enriched in smoking-high tumors, showing a pro-inflammatory phenotype in smoking-high LUSC, but an immunosuppressive phenotype in smoking-high HNSC. Complete expression data of smoking-high and smoking-low LUSC and HNSC (human papillomavirus–negative only) were analyzed for enrichment of GSEA hallmark gene sets, and results are plotted by color (normalized enrichment score; legend on the upper right) and size (–log false discovery rate [FDR]–adjusted P value; legend on the lower right, with * indicating FDR-adjusted P < .05). HNSC = head and neck squamous cell carcinoma; LUSC = lung squamous cell carcinoma; NES = normalized enrichment score.