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Model for Chromatin Reshaping during UVC Damage Repair by ANP32E and FACT Histone Chaperones
ANP32E removes H2A.Z from damaged chromatin, which may enhance chromatin accessibility. FACT subsequently promotes new H2A.X deposition coupled to repair synthesis and potentiates DNA damage signaling, thus contributing to coordinate signaling and repair of DNA damage. The resulting distribution of H2A.X in chromatin reflects DNA damage experience.
