Table 3.
Change in no. of bacterial colonies after treatment with NSAIDS (T2 vs. T1) and after additional treatment with low-concentration povidone-iodine (T3 vs. T2)
| NSAIDS | LC-PI | |
|---|---|---|
| T2 vs. T1 | T3 vs. T2 | |
| Change in no. of BC | ||
| Median (IQR1) | 0 (−40, 5) | −5 (−35, 0) |
| Min.-max. | (−280, 160) | (−500, 5) |
| Mean rank | ||
| Decrease (neg. rank) | 21.7 | 16.4 |
| Increase (pos. rank) | 17.3 | 3.5 |
| p-valuea | 0.068 | <0.001 |
| Change of ≥5 BC, any level (n, %) | ||
| No change (any level) | 12 (23.5) | 20 (39.2) |
| Change, either direction (±5 BC) | 39 (76.5) | 31 (60.8) |
| p-valueb | <0.001 | 0.12 |
| Decrease (≤−5, neg. rank) | 24 (61.5) | 30 96.8) |
| Increase (≥+5, pos. rank) | 15 (38.5) | 1 (3.2) |
| p-value (≤−5. vs. ≥+5)c | 0.20 | <0.001 |
| Change in BC-category (n, %)d | ||
| No change (≥5 or 0) | 34 (66.7) | 30 (58.8) |
| Change (≥5 to 0, 0 to ≥5) | 17 (33.3) | 21 (41.2) |
| p-valueb | 0.024 | 0.26 |
| No change, by BC-category | ||
| BC not identified (0 to 0) | 10 (29.4) | 19 63.3) |
| BC identified (≥5 to ≥5) | 24 (70.6) | 11 (36.7) |
| Change, by direction of change | ||
| Decrease (≥5 to 0) | 10 (58.8) | 20 (95.2) |
| Increase (0 to ≥5) | 7 (41.2) | 1 (4.8) |
| p-valuee | 0.63 | <0.001 |
BC bacterial colonies, LC-PI low-concentration povidone-iodine
aWilcoxon sign-rank test for change in specific direction (decrease vs. increase)
bChi-square test for difference in 2 independent proportions (change vs. no change)
cWilcoxon sign test for change in specific direction (decrease vs. increase)
dDichotomized into presence (BC ≥ 5) or absence (BC = 0) of bacteria
eMcNemar’s test for change in specific direction