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. 2018 Dec 13;8:17834. doi: 10.1038/s41598-018-36364-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Altered levels of Enterobacteriaceae (OTU23), Akkermansia (OTU41), and Anaerostipes (OTU71) following ivacaftor therapy. (A–C) All operational taxonomic units (OTUs) with greater than 10 reads were analyzed for significant differences following ivacaftor therapy using ANCOM. (D–I) Relative abundances of relevant OTUs were compared according to categorically negative (normal) or positive (abnormal) stool levels of M2PK and calprotectin for all stool samples (combined before and after ivacaftor). Normal values for faecal calprotectin and M2-PK were based on cut-offs of ≤50 mg/kg and ≤9U/ml. Means and 95% confidence intervals of each OTU’s relative abundance are shown.