Table 2.
Predictors of mortality in ET cases (Univariate Cox proportional-hazards models).
| Variable | Beta | HR | 95% CI | Significance |
|---|---|---|---|---|
| Age (years) | 0.15 | 1.16 | 1.08–1.24 | p <0.001 |
| Female gender | 0.12 | 1.13 | 0.51–2.51 | p = 0.76 |
| White race | 3.03 | 20.70 | 0.00–19162879.05 | p = 0.66 |
| Education (years) | −0.05 | 0.95 | 0.82–1.11 | p = 0.53 |
| Number of prescription medications | 0.011 | 1.01 | 0.95–1.08 | p = 0.76 |
| Current cigarette smoker | 0.47 | 1.59 | 0.24–11.87 | p = 0.65 |
| Age of tremor onset (years) | 0.009 | 1.01 | 0.99–1.03 | p = 0.34 |
| Total tremor score | 0.01 | 1.01 | 0.95–1.09 | p = 0.70 |
| MoCA score | −0.13 | 0.88 | 0.80–0.96 | p = 0.004 |
| Cognitive Diagnosis (Normal cognition, MCI, Dementia) | 0.79 | 2.20 | 1.38–3.52 | p = 0.001 |
| CDR | 1.51 | 4.53 | 2.48–8.28 | p <0.001 |
| Cognitive Domain | ||||
| Memory | −0.65 | 0.52 | 0.36–0.76 | p = 0.001 |
| Executive Function | −0.94 | 0.39 | 0.24–0.63 | p < 0.001 |
| Attention | −0.43 | 0.65 | 0.37–1.13 | p = 0.12 |
| Visuospatial Ability | −0.23 | 0.80 | 0.47–1.36 | p = 0.40 |
| Language | −0.67 | 0.51 | 0.32–0.82 | p = 0.005 |
| GDS | 0.06 | 1.07 | 1.001–1.14 | p = 0.048 |
| ABC | −0.02 | 0.98 | 0.96–0.99 | p = 0.006 |
| Number of falls reported during past year | 0.11 | 1.11 | 1.04–1.20 | p = 0.003 |
| Number of tandem mis-steps | 0.43 | 1.53 | 1.14–2.06 | p = 0.004 |
Bolded values are statistically significant (p < 0.05).
ABC, Activities-specific Balance Confidence Scale Short Form; CDR, Clinical Dementia Rating; CI, confidence interval; ET, essential tremor; GDS, Geriatric Depression Scale; HR, Hazards ratio; MCI, mild cognitive impairment; MoCA, Montreal Cognitive Assessment.