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. 2018 Nov 13;11:10–18. doi: 10.1016/j.dadm.2018.10.005

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 1 — (A) Size-exclusion chromatography of apoE particles in control and AD temporal lobe segregated by genotype. HPLC fractions were stained with anti-apoE monoclonal antibody (sc-13521) and analyzed densitometrically. Chromatograms are normalized to constant area. Values are mean ± SEM (N = 8 control ε3/ε3, 4 AD ε3/ε3, 5 AD ε3/ε4, 3 AD ε4/ε4). Robust repeated measures ANOVA F (4, 15) = 5.3, P = .0091. One way ANOVA F (4, 15) = 5.01, P = .0091. (B) Western blot of apoE HPLC fractions (autopsy sample, aged control). Abbreviations: AD, Alzheimer's disease; ANOVA, analysis of variance; apoE, apolipoprotein E; SEM, standard error of the mean.