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. 2018 Dec 12;21(1):132–145. doi: 10.1016/j.neo.2018.10.010

Figure 7.

Figure 7

Low stromal PTEN expression and collagen alignment correlate with high mammographic density. (A) Representative mammography for breasts classified as high or low density. (B) PTEN immunohistochemistry (brown) surrounding mammary ducts in low- and high-density breasts. (C) Stromal PTEN H score in low- and high-density breasts. (D) PTEN and hematoxylin staining (top row) and corresponding SHG images (bottom row) surrounding mammary ducts in low- and high-density breasts. (E) Histogram of fiber alignment relative to the duct edge. (F) Quantification of fiber alignment by the percent of fibers falling within 10° of the duct edge in low- and high-density breasts. (G) Correlation of collagen fiber alignment relative to the duct edge and stromal PTEN H score, P<.05 by Pearson's correlation. n=5 sections from low-density breasts, 8 high-density breasts, with images of 5 ducts taken per sample. *P<.05.