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. 2018 Sep 2;3(Suppl Suppl 2):180–190. doi: 10.1002/epi4.12253

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© 2018 The Authors. Epilepsia Open published by Wiley Periodicals Inc. on behalf of International League Against Epilepsy.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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A, Example traces showing the effects of everolimus on the frequency of sEPSCs recorded from 2 TSC cases. Cells were held at −70 mV to minimize the contribution of inhibitory synaptic activity and BIC (20 μm) was added to the ACSF. Long‐term (>15 min) application of everolimus reduced the frequency of sEPSCs and also decreased bursting activity (arrow), as well as the occurrence of large‐amplitude synaptic events. B, The bar graph indicates there was a statistically significant change in sEPSC frequency after everolimus (p = 0.01, paired t‐test, n = 8 cells).