Figure 5.

Anti–PD-1 antibody treatment enhances survival in a mouse model of LAM. (A) Kaplan-Meier analysis of survival in mice with Tsc2-null lung lesions. Mice were treated with either anti–PD-1 antibody (green) (n = 20) or isotype control IgG2a antibody (red) (n = 10). Animal survival was assessed as 20% loss of body weight. Statistical significance was determined for mice treated with anti–PD-1 antibody versus IgG2a antibody by log-sum rank test; P < 0.0001. (B) Percentage of lung lesions per lung in isotype control IgG2a- and anti–PD-1–treated mice at the time they were killed. Statistical analysis was performed using Student’s t test with P = 0.24. (C) Representative H&E images of lungs with Tsc2-null lesions from mice treated with either anti–PD-1 antibody or IgG2a at the time they were killed. Scale bars: 5 mm.