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. 2018 Aug 28;315(5):E1005–E1018. doi: 10.1152/ajpendo.00345.2017

Fig. 5.

Fig. 5.

Glutathione S-transferase (GST) pi-isoform (GSTP) deletion leads to glucose intolerance. Glycemic and metabolic parameters measured in age-matched (12–26-wk) male wild-type (WT) and GSTP-deficient (GSTP-null) mice. A: blood glucose levels in fed (WT, n = 5; GSTP-null, n = 9) and fasted (6 h: WT, n = 14; GSTP-null, n = 46; 16 h: WT, n = 7; GSTP-null, n = 11) mice. B and C: blood glucose levels during glucose tolerance test (GTT, B) and calculated area under the curve (GTTAUC, C) in WT and GSTP-null mice (WT, n = 15; GSTP-null, n = 47). D–F: fasting plasma insulin levels (WT, n = 26; GSTP-null, n = 34; D) and homeostatic model assessment of insulin resistance (HOMA-IR, E) and homeostatic model assessment of β-cell function (HOMA-%β, F) scores (WT, n = 23; GSTP-null, n = 32). G–L: metabolic parameters, oxygen consumption (V̇o2, G), carbon dioxide production (V̇co2, H), respiratory exchange ratio (RER, I), food consumption (J), water intake (K), and total activity (beam breaks per 12-h cycle, L), measured by indirect calorimetry in 13-wk-old male WT and GSTP-null mice (WT, n = 5; GSTP-null, n = 7). Values are means ± SE (*P < 0.05, WT vs. GSTP-null).