Fig. 6.
High fat diet-induced obesity and glucose intolerance in wild-type (WT) and glutathione S-transferase (GST) pi-isoform (GSTP)-deficient (GSTP-null) mice. A: cumulative body weight gain in WT and GSTP-null mice fed normal chow (NC, 12.5% kcal fat) or high-fat diet (HF, 60% kcal fat) for 6 wk. B: representative images and quantification of the dual-energy X-ray absorptiometry scanning and analysis of fat and lean mass in mice after 3 wk of NC or HFD feeding. C: blood glucose levels during glucose tolerance test (GTT) and calculated area under the curve (GTTAUC) in mice after 3.5 wk of diet (WT, n = 5; GSTP-null, n = 7). D: hepatic levels of triglycerides (TG, top) and total cholesterol (TC, bottom) measured in mice (WT-NC, n = 8; GSTP-null-NC, n = 10; WT-HF, n = 5; GSTP-null-HF, n = 5). Values are means ± SE (*P < 0.05, NC vs. HF or WT vs. GSTP-null as indicated).