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Schematic illustrating the parallel, sequential, and shared effects between our two models: high-fat diet feeding in wild-type mice (blue) and glutathione S-transferase pi-isoform (GSTP) depletion in GSTP-null mice (red) on glucose homeostasis via a hepatic-specific and JNK-dependent inflammatory process that increased hepatic gluconeogenesis and glucose intolerance, an early stage of metabolic dysregulation.
