Table 2.
Metabolic and plasma parameters of male WT and GSTP-null mice
| Parameter | WT | GSTP-Null |
|---|---|---|
| Body composition, g | ||
| Body weight | 29.57 ± 0.36 (24) | 29.36 ± 0.40 (23) |
| Lean mass | 21.04 ± 0.32 (24) | 21.34 ± 0.31 (23) |
| Fat mass | 4.88 ± 0.14 (24) | 4.56 ± 0.17 (23) |
| Organ weights, %body wt | ||
| Liver | 4.33 ± 0.11 (16) | 4.26 ± 0.09 (17) |
| WAT | 1.03 ± 0.09 (16) | 1.24 ± 0.08 (17) |
| BAT | 0.18 ± 0.02 (16) | 0.28 ± 0.01 (17)* |
| Plasma lipids, mg/dl | ||
| HDL-C | 75.65 ± 2.70 (8) | 74.97 ± 2.48 (18) |
| LDL-C | 11.67 ± 0.54 (8) | 12.84 ± 0.54 (18) |
| TG | 44.42 ± 2.73 (8) | 40.20 ± 2.12 (18) |
| Plasma biochemistry | ||
| Albumin, g/dl | 2.579 ± 0.07 (8) | 2.501 ± 0.03 (18) |
| Total protein, g/dl | 4.384 ± 0.08 (8) | 4.285 ± 0.05 (18) |
| CK, U/l | 234.7 ± 57.31 (6) | 190.8 ± 27.87 (15) |
| LDH, U/l | 205.6 ± 25.46 (6) | 164.8 ± 10.89 (15) |
| ALT, U/l | 55.95 ± 6.99 (6) | 35.49 ± 3.10 (15)* |
| AST, U/l | 79.98 ± 13.82 (6) | 57.18 ± 6.85 (15) |
Values are means ± SE; number of mice is in parentheses. ALT, alanine aminotransferase; AST, aspartate aminotransferase; BAT, brown adipose tissue; CK, creatine kinase; GSTP, glutathione S-transferase pi-isoform; HDL-C, high-density lipoprotein cholesterol; LDH, lactate dehydrogenase; LDL-C, low-density lipoprotein cholesterol; TG, triglycerides; WAT, white adipose tissue; WT, wild-type mice.
*
P < 0.05, WT vs. GSTP-null.