Effects of thyroid [triiodothyronine (T3)] and leptin repletion on energy expenditure. A: total energy expenditure (TEE). B: resting energy expenditure (REE). C: nonresting energy expenditure (NREE). FFM, fat-free mass; Wtinitial, usual body weight; Wt−10%placebo, body weight after 10% weight loss in subjects receiving 5 wk of placebo treatment; Wt−10%T3, body weight after 10% weight loss in subjects receiving 5 wk of T3 treatment; Wt−10%leptin, body weight after 10% weight loss in subjects receiving 5 wk of leptin treatment. Values are means (SD). *P < 0.05 vs. Wtinitial and body weight after 10% weight loss in T3- or leptin-repleted subjects (Wt−10%repleted); †P < 0.05 vs. Wtinitial.