Effects of thyroid hormone [triiodothyronine (T3), n = 9] and leptin (n = 10) repletion on 24-h urinary excretion of epinephrine (Epi) and norepinephrine (Norepi). Wtinitial, usual body weight; Wt−10%placebo, body weight after 10% weight loss in subjects receiving 5 wk of placebo treatment; Wt−10%T3, body weight after 10% weight loss in subjects receiving 5 wk of T3 treatment; Wt−10%leptin, body weight after 10% weight loss in subjects receiving 5 wk of leptin treatment. Values are means (SD). *P < 0.05 vs. Wtinitial and body weight after 10% weight loss in T3- or leptin-repleted subjects (Wt−10%repleted); †P < 0.05 vs. Wtinitial.