Table 1.
Subject characteristics
| Thyroid Repletion Studies [n = 9 (3 M, 6 F)] |
Leptin Repletion Studies [n = 22 (9 M, 13 F)] |
|||||
|---|---|---|---|---|---|---|
| Wtinitial | Wt−10%placebo | Wt−10%T3 | Wtinitial | Wt−10%placebo | Wt−10%leptin | |
| Age, yr | 32.2 (8.6) | 34.2 (8.1) | ||||
| Weight, kg | 97.5 (17.4) | 85.5 (13.8)* | 84.0 (14.0)*† | 114.6 (31.8) | 101.4 (29.6)* | 100.2 (29.0)*† |
| FFM, kg | 54.5 (9.3) | 52.6 (9.9)* | 51.6 (10.0)* | 62.4 (14.3) | 60.1 (14.0)* | 59.1 (14.0)* |
| FM, kg | 43.0 (17.0) | 32.9 (14.2)* | 32.4 (14.3)*† | 51.7 (22.6) | 42.3 (19.7)* | 41.1 (19.2)*† |
| %Body fat | 43.1 (11.6) | 38.0 (16.4)* | 37.1 (16.2)* | 43.4 (11.2) | 39.4 (10.9)* | 39.1 (11.3)* |
| Temperature, °C | 36.6 (0.3) | 36.7 (0.3) | 36.7 (0.3) | 36.5 (0.3) | 36.6 (0.3) | 36.5 (0.2) |
| Pulse, beats/min | 71 (9) | 68 (9)* | 73 (12)† | 72 (8) | 69 (8)* | 71 (8) |
| SBP, mmHg | 112 (9) | 110 (13) | 116 (9) | 113 (10) | 108 (12)* | 112 (11)† |
| DBP, mmHg | 65 (8) | 64 (7) | 67 (8) | 68 (8) | 67 (6) | 68 (7) |
| Serum T3, ng/dl | 101.7 (14.5) (range 84–131) | 93.8 (12.4)*(range 78–110) | 121.1 (12.9)*†(range 101–139 | 105.1 (19.0)(range 79–132) | 92.5 (17.7)*(range 61–127) | 101.9 (18.7)†(range 78–143) |
| Serum T4, μg/dl | 6.15 (1.11)(range 4.84–8.49) | 5.85 (1.12)(range 4.05–7.45) | 3.45 (1.74)*†(range 0.63–6.09) | 7.20 (0.99)(range 5.03–9.42) | 6.68 (0.93)*(range 5.38–9.32) | 7.32 (1.12)†(range 5.50–9.77) |
| Serum TSH, mU/l | 1.95 (0.65)(range 0.76–3.05) | 1.35 (0.74)*(range 0.86–2.84) | 0.51 (0.20)*†(range 0.04–1.71) | 1.63 (1.07)(range 0.71–4.97) | 1.23 (0.93)*(range 0.16–4.13) | 1.26 (1.06)*(range 0.18–4.45) |
| T4/T3 | 0.061 (0.013) | 0.067 (0.021) | 0.028 (0.016)*† | 0.070 (0.016) | 0.074 (0.018) | 0.073 (0.015) |
| Leptin, ng/ml | 39.7 (30.2) | 27.0 (22.9)* | 26.6 (22.3)* | 48.2 (44.3) | 34.9 (31.5)* | 54.4 (39.2)† |
Values are means (SD). FFM, fat-free mass; FM, fat mass; SBP and DBP, systolic and diastolic blood pressure; T3, triiodothyronine; T4, thyroxine; Wtinitial, usual body weight; Wt−10%placebo, body weight after 10% weight loss in subjects receiving 5 wk of placebo treatment; Wt−10%T3, body weight after 10% weight loss in subjects receiving 5 wk of T3 treatment; Wt−10%leptin, body weight after 10% weight loss in subjects receiving 5 wk of leptin treatment.
*
P < 0.05 vs. Wtinitial;
†
P < 0.05 vs. Wt−10%placebo.