Fig. 1.

Reduced uterine perfusion pressure (RUPP) produces maternal hypertension (A), reduced placental weight (B), and reduced fetal weight (C) by gestational day (GD) 19. RUPP reduces birth weight in both male and female offspring (D). *P < 0.05 vs. normal pregnant; **P < 0.05 vs. corresponding control offspring of same sex from normal pregnant dams. [Panel A adapted from Alexander et al. (6) with permission from Wolters Kluwer Health Inc. Copyright © 2001 American Heart Association Inc.; panels B and C adapted from Spradley et al. (191) with permission from Wolters Kluwer Health, Inc. Copyright © 2016 American Heart Association, Inc.; panel D adapted from Intapad et al. (95) with permission from Wolters Kluwer Health, Inc. Copyright © 2015 American Heart Association, Inc.]