Fig. 5.

Steatotic grade (A) and plasma small dense LDL (B) and circulating markers of liver injury ALT (C) and AST (D) in male intrauterine growth restriction (IUGR) offspring from calorically-restricted (CR) pregnant C57Bl/6 mice. All offspring were on high-fat diet (60% lipids) from 9 to 22 wk treated with vehicle or the endoplasmic reticulum stress inhibitor tauroursodeoxycholic acid (TUDCA; 0.5 g·kg⁻¹·day⁻¹). *P < 0.05 vs. vehicle-treated control rats from ad libitum dams; **P < 0.05 vs. TUDCA-treated control rats. #P < 0.05 vs. vehicle-treated controls. [Adapted from Muramatsu-Kato et al. (152), licensed under Creative Commons Attribution CC-BY 4.0.]