Table 3.

Group Differences and Interaction Effects With Total Brain Volume, Childhood IQ, and PRS.

Effect	Region	Cluster Size (mm2)	MNI Coordinates			P valuea	z Scoreb
			X	Y	Z
Group × TBV	R caudal middle frontal gyrus	2233.6	29.0	24.1	41.8	0.0002	2.63
Group × TBV	L lateral occipital gyrusc	1476.4	−12.1	−90.9	−8.4	0.0002	2.63
Group × TBV	L lingual gyrus	467.9	−26.6	−65.2	3.4	0.0100	1.82
Group	L middle temporal gyrus	505.1	−54.7	0.4	−28.5	0.0066	1.92
Group × IQ	L middle temporal gyrus	437.7	−54.7	0.4	−28.5	0.0149	1.72
Group × PRS	L medial orbito-frontal gyrus	791.1	−5.2	24.4	−19.4	0.0002	2.63

IQ, intelligence quotient; TBV, total brain volume; PRS, polygenic risk score.

Region and coordinates are based on the location of the cluster peak.

^aCluster-wise corrected P-value based on a precomputed Monte Carlo simulation with a z-distribution with a vertex-wise threshold of P <.001 and a cluster threshold of P <.05.

^bComputed by taking the inverse complementary error function of each cluster-wise P-value.

^cThe cluster peak was present in the lingual gyrus, but the majority of this cluster was in the lateral occipital gyrus and using that name avoids confusion about the 2 clusters.