Body fat percentages, BMI z scores, and serum LEP concentrations in patients with biallelic LEPR mutations. (A) Body fat percentage by sex (mean age females, 18.2 y; mean age males, 10.1 y; median females, 54.7%; median males 48.7%). (B) BMI z score by sex (mean age females, 15.8 y; mean age males, 7.8 y; median females, 4.95; median males, 4.5). (C) Serum LEP concentrations by sex (mean age females, 17.2 y; mean age males, 8.0 y; median females, 93.5 µg/L; median males, 58.4 µg/L). (D) Correlation of body fat percentage and serum LEP concentrations in females (mean age, 19.4 y; n = 9). (E) Correlation of body fat percentage and serum LEP concentrations in males (mean age, 10.1 y; n = 11).