Table 1.

LEPR Isoforms in Humans and Mice

Isoforms	Human	Mouse
Isoform A Alternative splicing	HuB or OB-R219.3:	LEPRa:
	p.897–1165 missing	p.895–1162 missing
	p.892–896: PETFE → RTDIL	p.890–894: PETFE → RTDTL
Isoform B Canonical sequence	HuB or OB-Rb/LEPRb: —	LEPRb: —
Isoform C Alternative splicing	HuB or OB-R219.1/LEPRa:	LEPRc:
	p.907–1165 missing	p.893–1162 missing
	p.892–958: PETFEHLFIK ... EKGSVCISDQ	p.890–892: PET → VTV
	→ MLEGSMFVKS ... KSPSVRNTQE
Isoform D Alternative splicing	HuB or OB-R219.2:	LEPRd:
	p.959–1165 missing	p.901–1162 missing
	p.892–906: PETFEHLFIKHTASV → KMPGTKELLGGGWLT	p.890–900: PETFEHLFTKH → DISFHEVFIFR
Isoform E Alternative splicing	sLEPR:	LEPRe/sLEPR:
	p.842–1165 missing	p.806–1162 missing
		p.797-805: DNFIPIEKY → GMCTVLFMD

Source: UniProt (mouse, http://www.uniprot.org/uniprot/P48356; human, http://www.uniprot.org/uniprot/P48357). Alternative nomenclature and protein sequence are given. LEPRb is the canonical sequence of LEPR. It is the most prevalent isoform, highly preserved among species, and has the longest amino acid sequence. LEPRb is the only isoform with clearly defined function and implications for body weight regulations.

Abbreviation: p., amino acid position in the protein.