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High phosphate (HP) challenge of PT-PTH1R−/− mice and PT-PTH1R/KL−/− mice. Levels of serum phosphate and fractional phosphate excretion (A) and levels of serum calcium and fractional calcium excretion (B) were measured in Control mice, PT-PTH1R−/− mice, and PT-PTH1R/KL−/− on normal phosphate (NP) and HP (50 mM phosphate) drinking water for 24 h (n = 6–9). Values of P < 0.05 were considered statistically significant. *P < 0.05, **P < 0.01, and ***P < 0.001. Data represent the means ± SD.
