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Phenotype comparison between the proximal tubule-specific deletion of Klotho, PTH1R, and PTH1R/Klotho
| PT-KL−/−* | PT-PTH1R−/− | PT-PTH1R/KL−/− | |
|---|---|---|---|
| Serum | |||
| Calcium | ↑ | — | — |
| Phosphate | ↑ | — | ↑ |
| FGF23 | — | ↑ | ↑ |
| PTH | — | ↑ | ↑↑ |
| 1,25(OH)2D3 | — | ↓ | ↓ |
| Urine | |||
| Ca | — | — | — |
| Pi | ↓↓ | — | — |
| BBM | |||
| NaPi2a | ↑ | — | ↑ |
Each strain is compared with Control mice (Slc34a1-Cre; Tomatofl/+). —, unchanged and/or normal; BBM, brush border membrane; FGF23, fibroblast growth factor 23; PTH, parathyroid hormone.
Reference 24.
