Table 4.
Regional differences in gray matter volume in AN patients compare with HC subjects identified in the two subgroup meta-analyses
| Region | Maximum | Cluster breakdowns | Jackknife sensitivity analysis | |||
|---|---|---|---|---|---|---|
| MNI coordinates x, y, z | SDM z-score | p-Value uncorrected | Number of voxels | |||
| Samples from AN adults (14 datasets) | ||||||
| Decreased GMV (AN < HC) | ||||||
| R fusiform gyrus | 32, −56, −18 | −2.113 | 0.001207650 | 137 | R fusiform (137) | 12 of 14 (D’Agata et al.; Fonville et al.) |
| R cerebellum | 30, −52, −22 | −2.045 | 0.001744330 | 433 | R cerebellum (433) | 14 of 14 |
| L cerebellum, | −24, −54, −28 | −2.432 | 0.000108361 | 898 | L cerebellum (733) | 14 of 14 |
| L median cingulate | −4, −30, 46 | −2.455 | 0.000098050 | 839 | L median cingulate (415) R median cingulate (84) L supplementary motor area (155) R supplementary motor area (60) R precuneus (36) L precuneus (82) L posterior cingulate gyrus (7) |
14 of 14 |
| Samples from pure AN patients (12 datasets) | ||||||
| Decreased GMV (AN < HC) | ||||||
| L supplementary motor area | −4, −18, 52 | −2.784 | ~0 | 1841 | L median cingulate (660) R median cingulate (422) L supplementary motor area (335) R supplementary motor area (189) L posterior cingulate gyrus (94) R posterior cingulate gyrus (41) R precuneus (82) L precuneus (18) |
12 of 12 |
| L amygdala | −30, −4, −20 | −1.773 | 0.002250135 | 130 | L amygdala (130) | 9 of 12 (Amianto et al., Friederich et al, MartinMonzon et al.) |
| L anterior cingulate | 2, 38, 24 | −1.746 | 0.002699077 | 43 | L anterior cingulate (43) | 9 of 12 (Kohmura et al., MartinMonzon et al., Van-opstal et al.) |
The jackknife sensitivity analysis column gives the number of studies whose omission does not affect the finding, and abbreviated reference citations for the remainder which do
BA Brodmann area, GM gray matter, MNI Montreal Neurological Institute Space, L left, R right, SDM seed-based d mapping