Table 3.

Selected SNPs to test “in vitro” functionality and to develop the AP-induced EPS pharmacogenetic predictor

Gene	SNP	A1	A2	IDa	Locationb	MAFc	HWEc	p-valuec,d	LDc, e	SiNoPsis	MAFf	HWEf	Codf	Domf	Recf	Overf	Addf
AKT1	rs1130214	G	T	A1	14:105259500–105261800	0.34	0.05	0.002	1.00	creSNP	0.33	0.308	0.04	0.147	0.136	0.02	0.654
	rs74090038	G	A	A2	14:105262088–105263088	0.32	0.06	0.028	0.83	creSNP	0.32	0.315	0.122	0.325	0.135	0.810	0.101
	rs67583154	C	T	A3	14:105265588–105267500	0.12	0.34	0.635	0.38	ecreSNP	0.15	0.436	0.305	0.317	0.335	0.206	0.480
	rs33925946	C	A	A4	14:105271000–105272088	0.30	0.07	0.032	0.67	creSNP	0.30	0.357	0.01	0.147	0.05	0.01	0.730
FCHSD1	rs1421896	A	C	F1	5:141015900–141017000	0.41	0.268	0.884	0.35	ecreSNP	0.37	0.889	0.822	0.830	0.624	0.591	0.931
	rs34798770	C	T	F2	5:141036800–141038500	0.34	0.829	0.246	0.25	creSNP	0.44	0.795	0.818	0.628	0.898	0.582	0.808
DDIT4	rs1053639	T	A	D1	10:74034943–74035797	0.37	0.492	0.002	1.00	ecreSNP	0.41	0.894	0.381	0.984	0.189	0.328	0.470
	rs4747241	C	T	D2	10:74035797–74036678	0.38	0.364	0.004	0.64	ecreSNP	0.42	0.594	0.414	0.715	0.286	0.235	0.731
	rs4747242	A	C	D3	10:74036797–74037678	0.37	0.492	0.002	0.92	ecreSNP	0.40	0.596	0.386	0.847	0.177	0.401	0.392
	rs10823911	A	C	D4	10:74039870–74040480	0.18	0.821	0.008	0.92	eSNP	0.40	0.689	0.413	0.801	0.189	0.452	0.380
Raptor	rs34726568	T	TA	R1	17:78518000–78521100	0.16	1	0.002	0.07	ecreSNP	0.21	0.558	0.03	0.184	0.01	0.752	0.05
	rs9899898	G	A	R2	17:78578583–78580283	0.34	0.06	0.026	0.48	ecreSNP	0.33	0.04	0.665	0.385	0.654	0.539	0.371
	rs9915667	A	G	R3	17:78753340–78756340	0.41	0.246	0.002	0.19	ecreSNP	0.45	0.516	0.05	0.04	0.04	0.799	0.01

MAF minimum allele frequency, HWE Hardy–Weinberg equilibrium, LD linkage disequilibrium, Cod codominant, Dom dominant, Rec recessive, Over overdominant, Add logg-additive

Summary of the genetic association analysis of AP-induced EPS performed in the Discovery cohort (N = 131). The p-value of each inheritance model is show. Each model was adjust by age, sex and dosage. In bold, nominal significant p-values are shown

^aRegion code identifier used throughout the manuscript

^bLocation of the fragment cloned upstream of the Luc2P gene according to GRCh37/hg19

^cCalculated with the 88 samples of the Discovery cohort that where re-sequenced

^dp-value of the best model (codominant, dominant, recessive, overdominant, log-additive) in the preliminary association test

^eLD with the variant of the original predictor for each gene

^fCalculated with the Discovery cohort (N = 131)