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. 2018 Nov 16;37(24):e100409. doi: 10.15252/embj.2018100409

Figure EV4. Hematopoietic recovery in PKCδ fl/fl and PKCδ cKO mice after 5‐FU treatment.

Figure EV4

  • A, B
    (A) Experimental design, (B) kinetics of white blood cells (WBC), red blood cells (RBC), and platelet cell recovery in peripheral blood of WT and cKO mice after single dose of 5‐FU treatment (n = 8–12 mice per genotype).
  • C
    Representative hematoxylin–eosin (H&E)‐stained femur sections from indicated mice at day 4 of 13 and 28 after a single injection of 5‐FU treatment (bottom) (n = 4–5 mice per time point for each genotype).
  • D
    Enlarged spleen in PKCδ Δ/Δ (cKO) mice during recovery phase (d13) after 5‐FU treatment. Spleen size of WT and cKO mice at indicated time points after 5‐FU treatment.
Data information: All data are presented as mean ± SEM, by repeated measures two‐way ANOVA analysis with Sidak's multiple comparison tests (B) for comparison of control and PKCδ cKO mice at each time point. *P < 0.05.