Table 1.
Analyses of socioeconomic and health characteristics predictors for different levels of recruitment for Insight 46, with no adjustments
| Variable | A. Specific life course data available Max n = 2689 |
B. Willingness for London-clinic Max n = 1322 |
C. Attended Max n = 841 |
D. Scanned Max n = 502 |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | P | 95% CI | OR | P | 95% CI | OR | P | 95% CI | OR | P | 95% CI | |
| Sex | ||||||||||||
| Female | Reference | Reference | Reference | Reference | ||||||||
| Male | 1.19 | 0.03 | 1.02, 1.38 | 0.92 | 0.48 | 0.74, 1.15 | 0.77 | 0.07 | 0.59, 1.02 | 0.89 | 0.76 | 0.43, 1.85 |
| Childhood SEP | ||||||||||||
| Manual | Reference | Reference | Reference | Reference | ||||||||
| Non-manual | 1.58 | < 0.01 | 1.35, 1.85 | 1.57 | < 0.01 | 1.26, 1.96 | 1.18 | 0.24 | 0.90, 1.56 | 2.04 | 0.06 | 0.96, 4.33 |
| Educational attainment to age 26 | ||||||||||||
| None | Reference | Reference | Reference | Reference | ||||||||
| Up to GCE (age 16) | 2.03 | < 0.01 | 1.66, 2.48 | 1.55 | < 0.01 | 1.15, 2.08 | 1.74 | 0.01 | 1.16, 2.61 | 0.85 | 0.80 | 0.25, 2.86 |
| A-level and above (age 16+) | 3.09 | < 0.01 | 2.55, 3.73 | 2.29 | < 0.01 | 1.74, 3.02 | 1.76 | < 0.01 | 1.22, 2.54 | 0.77 | 0.64 | 0.25, 2.33 |
| Adult SEP | ||||||||||||
| Manual | Reference | Reference | Reference | Reference | ||||||||
| Non-manual | 2.22 | < 0.01 | 1.88, 2.63 | 1.88 | < 0.01 | 1.45, 2.43 | 1.70 | < 0.01 | 1.20, 2.42 | 1.08 | 0.87 | 0.40, 2.92 |
| Childhood cognitive score | ||||||||||||
| Bottom 10% | Reference | Reference | Reference | Reference | ||||||||
| Middle 80% | 2.84 | < 0.01 | 2.08, 3.88 | 2.60 | < 0.01 | 1.52, 4.45 | 1.45 | 0.35 | 0.66, 3.18 | 1.20 | 0.87 | 0.15, 9.56 |
| Top 10% | 3.23 | < 0.01 | 2.19, 4.75 | 3.10 | < 0.01 | 1.67, 5.75 | 1.90 | 0.15 | 0.80, 4.49 | 1.97 | 0.57 | 0.19, 20.56 |
| Word learning test memory score at 69 years | ||||||||||||
| Bottom 10% | Reference | Reference | Reference | Reference | ||||||||
| Middle 80% | 1.64 | < 0.01 | 1.24, 2.17 | 1.51 | 0.05 | 1.00, 2.27 | 1.60 | 0.10 | 0.92, 2.80 | 1.21 | 0.80 | 0.27, 5.41 |
| Top 10% | 2.45 | < 0.01 | 1.63, 3.69 | 1.78 | 0.04 | 1.04, 3.03 | 2.11 | 0.04 | 1.05, 4.23 | 1.49 | 0.67 | 0.23, 9.50 |
| Mental health prevalence at age 69 | ||||||||||||
| No | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.71 | 0.01 | 0.56, 0.91 | 0.77 | 0.14 | 0.55, 1.09 | 0.42 | < 0.01 | 0.27, 0.66 | 0.30 | 0.01 | 0.11, 0.78 |
| Lifetime smoking by 69 years | ||||||||||||
| Never smoker | Reference | Reference | Reference | Reference | ||||||||
| Ex-smoker | 0.94 | 0.47 | 0.79, 1.12 | 0.90 | 0.38 | 0.70, 1.14 | 1.00 | 1.00 | 0.74, 1.35 | 0.48 | 0.12 | 0.19, 1.20 |
| Current smoker | 0.51 | < 0.01 | 0.38, 0.68 | 0.54 | 0.01 | 0.34, 0.86 | 0.43 | 0.01 | 0.23, 0.82 | 0.34 | 0.15 | 0.05, 1.58 |
| Alcohol use at age 69 | ||||||||||||
| Never | Reference | Reference | Reference | Reference | ||||||||
| Less than once a week | 1.17 | 0.27 | 0.89, 1.54 | 0.93 | 0.72 | 0.64, 1.37 | 1.32 | 0.27 | 0.81, 2.16 | 0.32 | 0.18 | 0.03, 1.95 |
| 2–3× per week | 1.38 | 0.03 | 1.03, 1.85 | 1.48 | 0.06 | 0.99, 2.21 | 2.16 | < 0.01 | 1.30, 3.59 | 0.36 | 0.35 | 0.04, 2.96 |
| 4+ times per week | 1.37 | 0.03 | 1.03, 1.83 | 1.36 | 0.12 | 0.92, 2.01 | 1.51 | 0.10 | 0.93, 2.47 | 0.44 | 0.44 | 0.05, 3.58 |
| Weight status at age 69 | ||||||||||||
| Underweight or normal | Reference | Reference | Reference | Reference | ||||||||
| Overweight | 0.70 | < 0.01 | 0.57, 0.87 | 0.83 | 0.17 | 0.63, 1.08 | 1.59 | 0.01 | 1.14, 2.22 | 0.50 | 0.25 | 0.16, 1.61 |
| Obese | 0.59 | < 0.01 | 0.47, 0.74 | 0.83 | 0.23 | 0.62, 1.12 | 1.33 | 0.12 | 0.93, 1.92 | 0.22 | 0.01 | 0.07, 0.69 |
| Type II diabetes by age 69 | ||||||||||||
| No | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.69 | < 0.01 | 0.54, 0.88 | 0.95 | 0.79 | 0.65, 1.38 | 1.18 | 0.49 | 0.73, 1.91 | 0.76 | 0.62 | 0.25, 2.27 |
| Hypertension by age 69 | ||||||||||||
| No | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.60 | < 0.01 | 0.51, 0.71 | 0.83 | 0.11 | 0.66, 1.04 | 0.92 | 0.54 | 0.69, 1.21 | 1.05 | 0.89 | 0.50, 2.19 |
| Overall disease burden by age 69 | ||||||||||||
| None | Reference | Reference | Reference | Reference | ||||||||
| 1 | 0.87 | 0.27 | 0.69, 1.11 | 1.36 | 0.05 | 1.00, 1.84 | 0.82 | 0.29 | 0.56, 1.19 | 1.09 | 0.86 | 0.42, 2.85 |
| 2 | 0.81 | 0.12 | 0.62, 1.06 | 1.00 | 1.00 | 0.71, 1.41 | 0.86 | 0.50 | 0.55, 1.33 | 0.98 | 0.97 | 0.33, 2.91 |
| 3+ | 0.67 | < 0.01 | 0.51, 0.88 | 1.14 | 0.47 | 0.80, 1.63 | 0.59 | 0.02 | 0.38, 0.92 | 0.74 | 0.59 | 0.25, 2.21 |
| Self-rated health at age 68 | ||||||||||||
| Poor | Reference | Reference | Reference | Reference | ||||||||
| Fair | 1.22 | 0.45 | 0.73, 2.02 | 1.43 | 0.38 | 0.64, 3.19 | 1.49 | 0.54 | 0.42, 5.22 | 0.35 | 0.19 | 0.07, 1.67 |
| Good | 1.57 | 0.07 | 0.97, 2.54 | 1.64 | 0.20 | 0.77, 3.51 | 2.97 | 0.08 | 0.89, 9.92 | 0.61 | 0.46 | 0.16, 2.29 |
| Very good | 2.49 | < 0.01 | 1.54, 4.04 | 2.11 | 0.05 | 0.99, 4.47 | 4.39 | 0.02 | 1.33, 14.54 | 0.80 | 0.74 | 0.22, 2.88 |
| Excellent | 2.34 | < 0.01 | 1.37, 4.00 | 2.98 | 0.01 | 1.31, 6.79 | 4.18 | 0.03 | 1.20, 14.55 | 1.00 | - | 1.00, 1.00 |
| APOE status | ||||||||||||
| No e4 | Reference | Reference | Reference | Reference | ||||||||
| e4 heterozygous | 0.87 | 0.19 | 0.72, 1.07 | 0.99 | 0.96 | 0.75, 1.31 | 0.98 | 0.93 | 0.69, 1.41 | 1.16 | 0.76 | 0.45, 2.95 |
| e4 homozygous | 1.26 | 0.37 | 0.76, 2.07 | 0.70 | 0.28 | 0.37, 1.33 | 0.91 | 0.83 | 0.36, 2.25 | 0.76 | 0.80 | 0.09, 6.21 |
| Residential distance from London centre (miles) | ||||||||||||
| < 60 | Reference | Reference | Reference | Reference | ||||||||
| 60–120 | 0.92 | 0.42 | 0.75, 1.13 | 0.68 | 0.02 | 0.50, 0.93 | 1.35 | 0.09 | 0.95, 1.93 | NA | ||
| 120–180 | 0.91 | 0.39 | 0.74, 1.13 | 0.39 | < 0.01 | 0.29, 0.54 | 1.13 | 0.53 | 0.77, 1.67 | |||
| > 180 | 0.86 | 0.17 | 0.69, 1.07 | 0.38 | < 0.01 | 0.27, 0.52 | 1.07 | 0.75 | 0.71, 1.60 | |||
SEP: socioeconomic position; OR: odds ratio; A: Comparing those who did not meet the specific life course data availability criteria vs those who did; B: comparing those who previously indicated they were not willing to attend a London-based clinic or did not respond vs those who were; C: comparing those who did not attend vs successfully attended; D: comparing those who were not scanned vs those successfully scanned
Italic values indicate p < 0.05