Table 2.
Socioeconomic and health characteristics predictors of levels of recruitment for Insight 46, adjusting for sex, childhood and adult SEP and education
| Variable | A. Specific life course data available | B. Willingness for London-clinic | C. Attended | D. Scanned | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | P | 95% CI | OR | P | 95% CI | OR | P | 95% CI | OR | P | 95% CI | |
| Childhood cognitive score | ||||||||||||
| Bottom 10% | Reference | Reference | Reference | Reference | ||||||||
| Middle 80% | 1.55 | 0.01 | 1.10, 2.19 | 1.66 | 0.07 | 0.96, 2.90 | 1.06 | 0.89 | 0.45, 2.48 | 1.26 | 0.84 | 0.14, 11.54 |
| Top 10% | 1.06 | 0.79 | 0.68, 1.65 | 1.78 | 0.09 | 0.92, 3.44 | 1.28 | 0.60 | 0.50, 3.30 | 2.07 | 0.57 | 0.17, 25.65 |
| Word learning test memory score at 69 years | ||||||||||||
| Bottom 10% | Reference | Reference | Reference | Reference | ||||||||
| Middle 80% | 1.25 | 0.16 | 0.92, 1.70 | 1.27 | 0.28 | 0.82, 1.94 | 1.40 | 0.26 | 0.79, 2.49 | 1.15 | 0.86 | 0.25, 5.29 |
| Top 10% | 1.56 | 0.07 | 0.97, 2.50 | 1.25 | 0.45 | 0.71, 2.21 | 1.77 | 0.13 | 0.85, 3.68 | 1.32 | 0.78 | 0.19, 8.94 |
| Mental health prevalence at age 69 | ||||||||||||
| No | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.78 | 0.07 | 0.59, 1.02 | 0.91 | 0.60 | 0.63, 1.30 | 0.46 | < 0.01 | 0.29, 0.73 | 0.28 | 0.01 | 0.10, 0.75 |
| Lifetime smoking to 69 years | ||||||||||||
| Never smoker | Reference | Reference | Reference | Reference | ||||||||
| Ex-smoker | 0.98 | 0.86 | 0.81, 1.19 | 0.90 | 0.42 | 0.70, 1.16 | 0.99 | 0.97 | 0.73, 1.35 | 0.47 | 0.11 | 0.18, 1.18 |
| Current smoker | 0.64 | 0.01 | 0.46, 0.88 | 0.70 | 0.14 | 0.43, 1.12 | 0.48 | 0.03 | 0.25, 0.94 | 0.33 | 0.21 | 0.06, 1.86 |
| Alcohol use at age 69 | ||||||||||||
| Never | Reference | Reference | Reference | Reference | ||||||||
| Less than once a week | 1.09 | 0.58 | 0.80, 1.48 | 0.91 | 0.63 | 0.61, 1.35 | 1.28 | 0.34 | 0.77, 2.13 | 0.32 | 0.29 | 0.04, 2.62 |
| 2–3× per week | 1.21 | 0.25 | 0.87, 1.68 | 1.22 | 0.35 | 0.80, 1.85 | 1.91 | 0.02 | 1.13, 3.25 | 0.45 | 0.46 | 0.05, 3.73 |
| 4+ times per week | 1.17 | 0.35 | 0.84, 1.61 | 1.11 | 0.62 | 0.74, 1.67 | 1.29 | 0.33 | 0.77, 2.16 | 0.54 | 0.57 | 0.06, 4.63 |
| Overweight at age 69 | ||||||||||||
| No | Reference | Reference | Reference | Reference | ||||||||
| Overweight | 0.74 | 0.01 | 0.58, 0.94 | 0.89 | 0.40 | 0.67, 1.17 | 1.61 | 0.01 | 1.14, 2.28 | 0.39 | 0.15 | 0.10, 1.43 |
| Obese | 0.67 | < 0.01 | 0.52, 0.86 | 0.95 | 0.72 | 0.70, 1.28 | 1.45 | 0.05 | 0.99, 2.12 | 0.17 | 0.01 | 0.05, 0.62 |
| Type II diabetes at age 69 | ||||||||||||
| No | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.83 | 0.18 | 0.63, 1.09 | 1.04 | 0.85 | 0.70, 1.53 | 1.21 | 0.46 | 0.73, 2.01 | 0.68 | 0.50 | 0.22, 2.06 |
| Hypertension by age 69 | ||||||||||||
| No | Reference | Reference | Reference | Reference | ||||||||
| Yes | 0.61 | < 0.01 | 0.51, 0.73 | 0.86 | 0.21 | 0.69, 1.09 | 0.92 | 0.58 | 0.69, 1.23 | 0.98 | 0.94 | 0.46, 2.07 |
| Overall disease burden at age 69 | ||||||||||||
| None | Reference | Reference | Reference | Reference | ||||||||
| 1 | 0.81 | 0.13 | 0.62, 1.06 | 1.31 | 0.09 | 0.96, 1.78 | 0.79 | 0.24 | 0.54, 1.16 | 1.18 | 0.74 | 0.45, 3.12 |
| 2 | 0.70 | 0.02 | 0.52, 0.94 | 1.01 | 0.94 | 0.71, 1.44 | 0.84 | 0.44 | 0.53, 1.31 | 1.15 | 0.81 | 0.36, 3.67 |
| 3+ | 0.72 | 0.03 | 0.53, 0.97 | 1.23 | 0.28 | 0.85, 1.77 | 0.63 | 0.04 | 0.40, 0.99 | 0.71 | 0.54 | 0.23, 2.15 |
| Self-rated health at age 68 | ||||||||||||
| Poor | Reference | Reference | Reference | Reference | ||||||||
| Fair | 1.05 | 0.85 | 0.62, 1.80 | 1.35 | 0.47 | 0.59, 3.08 | 1.40 | 0.61 | 0.39, 5.05 | 0.37 | 0.22 | 0.08, 1.81 |
| Good | 1.30 | 0.31 | 0.78, 2.17 | 1.36 | 0.44 | 0.62, 2.97 | 2.66 | 0.12 | 0.77, 9.15 | 0.61 | 0.47 | 0.16, 2.35 |
| Very good | 1.93 | 0.01 | 1.16, 3.22 | 1.65 | 0.21 | 0.76, 3.58 | 3.75 | 0.04 | 1.10, 12.77 | 0.91 | 0.88 | 0.25, 3.32 |
| Excellent | 1.97 | 0.02 | 1.11, 3.50 | 2.07 | 0.09 | 0.89, 4.82 | 3.42 | 0.06 | 0.95, 12.29 | 1.00 | - | 1.00, 1.00 |
| APOE status | ||||||||||||
| No e4 | Reference | Reference | Reference | Reference | ||||||||
| e4 heterozygous | 0.85 | 0.13 | 0.68, 1.05 | 0.99 | 0.97 | 0.75, 1.32 | 0.98 | 0.93 | 0.68, 1.42 | 1.08 | 0.88 | 0.41, 2.80 |
| e4 homozygous | 1.27 | 0.39 | 0.73, 2.21 | 0.79 | 0.50 | 0.40, 1.56 | 0.97 | 0.95 | 0.38, 2.46 | 0.66 | 0.70 | 0.08, 5.46 |
| Residential distance to London centre (miles) | ||||||||||||
| < 60 | Reference | Reference | Reference | Reference | ||||||||
| 60–120 | 0.99 | 0.92 | 0.79, 1.24 | 0.65 | 0.01 | 0.48, 0.90 | 1.21 | 0.09 | 0.96, 2.16 | NA | ||
| 120–180 | 0.99 | 0.91 | 0.78, 1.24 | 0.40 | < 0.01 | 0.29, 0.55 | 1.19 | 0.39 | 0.80, 1.78 | |||
| > 180 | 0.87 | 0.24 | 0.68, 1.10 | 0.36 | < 0.01 | 0.26, 0.50 | 1.11 | 0.62 | 0.73, 1.68 | |||
SEP: socioeconomic position; OR: odds ratio. A: Comparing those that didn’t meet the specific life course data availability criteria vs those who did; B: comparing those that previously indicated they were not willing to attend a London-based clinic or didn’t respond vs those who were; C: comparing those that didn’t attend vs successfully attended; D: comparing those who were not scanned vs those successfully scanned
Italic values indicate p < 0.05