Table 4.
Antimicrobial susceptibility among Gram-positive isolates including multi-drug resistance(MDR) strains from blood specimens collected between 2012 and 2016
| Africa | Asia | Europe | North America | Latin America | Global | Global | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| S% | S% | S% | S% | S% | MIC90(mg/L) | MIC range(mg/L) | S% | R% | MIC90(mg/L) | MIC range(mg/L) | S% | R% | |
| S.aureus | S.aureus, all isolates | MRSA | |||||||||||
| N = 43 | N = 298 | N = 2008 | N = 814 | N = 161 | N = 3324 | N = 1096 | |||||||
| Levofloxacin | 65.1 | 57.4 | 69.3 | 67.3 | 77.0 | 16 | 0.06–64 | 68.1 | 30.2 | 64 | 0.06–64 | 21.9 | 75.6 |
| Linezolid | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 2 | 0.5–4 | 100.0 | 0.0 | 2 | 0.5–4 | 100.0 | 0.0 |
| Minocycline | 83.7 | 97.3 | 99.5 | 98.3 | 100.0 | 0.25 | 0.25–16 | 98.8 | 0.1 | 0.5 | 0.25–16 | 97.5 | 0.1 |
| Penicillin | 2.3 | 6.0 | 15.9 | 16.6 | 8.1 | 16 | 0.06–16 | 14.7 | 85.4 | 16 | 0.12–16 | 0.1 | 99.9 |
| Tigecycline | 100 | 99.7 | 100.0 | 100.0 | 100.0 | 0.12 | 0.008–1 | 99.9 | 0.0 | 0.25 | 0.015–1 | 99.9 | 0.0 |
| Vancomycin | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 1 | 0.12–2 | 100.0 | 0.0 | 1 | 0.12–2 | 100.0 | 0.0 |
| E.faecalis | E.faecalis, all isolates | VR E.faecalis | |||||||||||
| N = 26 | N = 99 | N = 910 | N = 406 | N = 86 | N = 1527 | N = 22 | |||||||
| Ampicillin | 100.0 | 96.0 | 98.9 | 99.8 | 96.5 | 1 | 0.06–32 | 98.8 | 1.2 | 32 | 0.5–32 | 86.4 | 13.6 |
| Levofloxacin | 69.2 | 70.7 | 68.6 | 73.4 | 81.4 | 64 | 0.06–64 | 70.7 | 28.5 | 64 | 0.5–64 | 13.6 | 86.4 |
| Linezolid | 100.0 | 97.0 | 100.0 | 100.0 | 97.7 | 2 | 0.5–8 | 99.7 | 0.1 | 2 | 0.5–2 | 100.0 | 0.0 |
| Minocycline | 30.8 | 35.4 | 36.8 | 35.2 | 38.4 | 8 | 0.25–16 | 36.3 | 6.3 | 8 | 0.25–8 | 27.3 | 0.0 |
| Penicillin | 100.0 | 95.0 | 98.8 | 99.8 | 96.5 | 4 | 0.06–16 | 98.7 | 1.3 | 16 | 2–16 | 86.4 | 13.6 |
| Tigecycline | 100.0 | 100.0 | 99.9 | 100.0 | 100.0 | 0.12 | 0.008–0.5 | 100.0 | 0.0 | 0.12 | 0.03–0.12 | 100.0 | 0.0 |
| Vancomycin | 96.2 | 98.0 | 99.0 | 96.6 | 98.8 | 2 | 0.12–64 | 98.2 | 1.4 | 64 | 32–64 | 0.0 | 100.0 |
| E.faecium | E.faecium, all isolates | VR E.faecium | |||||||||||
| N = 9 | N = 89 | N = 603 | N = 268 | N = 31 | N = 1000 | N = 276 | |||||||
| Ampicillin | 11.1 | 12.4 | 11.1 | 14.2 | 6.5 | 32 | 0.06–32 | 11.9 | 88.1 | 32 | 4–32 | 0.7 | 99.3 |
| Levofloxacin | 22.2 | 9.0 | 9.8 | 12.3 | 12.9 | 64 | 0.06–64 | 10.6 | 87.0 | 64 | 8–64 | 0.0 | 100.0 |
| Linezolid | 100.0 | 100.0 | 99.7 | 98.8 | 100.0 | 2 | 0.5–8 | 99.5 | 0.2 | 2 | 0.5–8 | 98.9 | 0.4 |
| Minocycline | 88.9 | 47.2 | 70.2 | 59.0 | 80.7 | 8 | 0.25–16 | 65.6 | 6.2 | 8 | 0.25–16 | 58.7 | 6.2 |
| Penicillin | 11.1 | 14.6 | 13.1 | 12.7 | 6.5 | 16 | 0.06–16 | 12.9 | 87.1 | 16 | 4–16 | 1.5 | 98.6 |
| Tigecycline | 100.0 | 100.0 | 99.5 | 98.9 | 100.0 | 0.12 | 0.008–1 | 99.4 | 0.0 | 0.12 | 0.008–1 | 98.9 | 0.0 |
| Vancomycin | 66.7 | 78.7 | 87.1 | 38.1 | 41.9 | 64 | 0.12–64 | 71.6 | 27.6 | 64 | 32–64 | 0.0 | 100.0 |
| S.pneumoniae | S.pneumoniae, all isolates | PR S.pneumoniae | |||||||||||
| N = 23 | N = 66 | N = 1248 | N = 553 | N = 93 | N = 1983 | N = 178 | |||||||
| Amoxy/clav | 91.3 | 95.5 | 98.0 | 96.2 | 93.6 | 1 | 0.03–16 | 97.1 | 1.1 | 8 | 0.03–16 | 68.5 | 11.8 |
| Azithromycin | 69.6 | 38.1 | 81.1 | 63.0 | 44.6 | 64 | 0.03–512 | 72.7 | 26.0 | 128 | 0.03–512 | 28.7 | 69.0 |
| Ceftriaxone | 100.0 | 94.0 | 98.7 | 99.0 | 98.9 | 0.5 | 0.03–8 | 98.6 | 0.1 | 2 | 0.03–8 | 86.0 | 1.1 |
| Clarithromycin | 69.6 | 39.7 | 80.9 | 63.0 | 69.6 | 128 | 0.015–128 | 73.9 | 26.0 | 128 | 0.015–128 | 30.5 | 69.0 |
| Clindamycin | 78.3 | 61.9 | 85.3 | 87.4 | 79.4 | 128 | 0.015–128 | 84.7 | 14.8 | 128 | 0.015–128 | 53.5 | 45.4 |
| Erythromycin | 69.6 | 39.7 | 80.8 | 63.6 | 69.6 | 64 | 0.015–128 | 74.0 | 25.8 | 128 | 0.015–128 | 29.9 | 69.0 |
| Levofloxacin | 100.0 | 98.5 | 99.6 | 99.6 | 98.9 | 1 | 0.06–16 | 99.6 | 0.4 | 1 | 0.12–16 | 99.4 | 0.6 |
| Linezolid | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 1 | 0.5–2 | 100.0 | 0.0 | 1 | 0.5–2 | 100.0 | 0.0 |
| Meropenem | 81.0 | 60.6 | 89.7 | 87.0 | 86.0 | 0.5 | 0.12–8 | 87.8 | 7.1 | 1 | 0.12–8 | 3.4 | 70.8 |
| Minocycline | 73.9 | 37.9 | 77.5 | 83.7 | 69.9 | 4 | 0.25–16 | 77.5 | 16.8 | 8 | 0.25–16 | 46.1 | 45.0 |
| Penicillin | 69.6 | 34.9 | 70.4 | 69.8 | 55.9 | 1 | 0.06–16 | 68.3 | 9.0 | 4 | 2–16 | 0.0 | 100.0 |
| Tigecycline | 100.0 | 98.5 | 99.8 | 99.5 | 100.0 | 0.03 | 0.008–4 | 99.7 | 0.0 | 0.03 | 0.008–0.12 | 100.0 | 0.0 |
| Vancomycin | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 0.5 | 0.12–1 | 100.0 | 0.0 | 0.5 | 0.12–1 | 100.0 | 0.0 |
| S.agalactiae | |||||||||||||
| N = 8 | N = 64 | N = 505 | N = 373 | N = 32 | N = 982 | ||||||||
| Ampicillin | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 0.12 | 0.06–0.25 | 100.0 | 0.0 | ||||
| Ceftriaxone | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 0.12 | 0.03–0.5 | 100.0 | 0.0 | ||||
| Levofloxacin | 100.0 | 95.3 | 98.2 | 96.5 | 87.5 | 1 | 0.06–64 | 97.1 | 2.7 | ||||
| Linezolid | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 1 | 0.5–2 | 100.0 | 0.0 | ||||
| Meropenem | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 0.12 | 0.12–0.5 | 100.0 | 0.0 | ||||
| Minocycline | 12.5 | 20.3 | 17.8 | 22.0 | 50.0 | 16 | 0.25–16 | 20.6 | 62.7 | ||||
| Penicillin | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 0.12 | 0.06–0.12 | 100.0 | 0.0 | ||||
| Tigecycline | 100.0 | 96.9 | 99.8 | 100.0 | 100.0 | 0.06 | 0.008–4 | 99.7 | 0.0 | ||||
| Vancomycin | 100.0 | 100.0 | 100.0 | 100.0 | 100.0 | 0.5 | 0.12–1 | 100.0 | 0.0 | ||||
Abbreviations: S% percentage of susceptible isolates, R% percentage of resistant isolates, MIC minimum inhibitory concentration, Amoxy/clav Amoxicillin/clavulanic acid