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. Author manuscript; available in PMC: 2019 Feb 14.
Published in final edited form as: Biochem J. 2018 Feb 14;475(3):677–690. doi: 10.1042/BCJ20170672

Figure 7: Model for SRPK1-Stimulated Phosphorylation and Nuclear Mobilization of SRSF1 Through CLK1.

Figure 7:

SRPK1 supports movement of SRSF1 from speckles to nucleoplasm using two pathways. In pathway A, the SRPK1-CLK1 complex directly enhances the phosphorylation rate of SRSF1. In pathway B, SRPK1 dissociates CLK1 from phospho-SRSF1 stabilizing Ser-Pro phosphates on the RS domain.