Table 1.
Baseline data for participants with typical or atypical BDNF genotype. A two-sided t-test was used to compare the two groups on each baseline behavioral test, age, years of education, and lesion size. Significant group differences are highlighted by bolded text for the p-values in the last column.
| Baseline Characteristic | Typical BDNF genotype (val/val) N = 36 |
Atypical BDNF (val/met, met/met) N = 30 |
Two sided p-value | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Mean | SD | Lower 95% CI | Upper 95% CI | Mean | SD | Lower 95% CI | Upper 95% CI | ||
| WAB-R AQ | 63.5 | 18.6 | 57.2 | 69.8 | 52.2 | 19.3 | 45 | 59.4 | 0.01 |
| Naming 80 (treated items) | 23.0 | 18.0 | 16.9 | 29.1 | 14.4 | 15 | 8.8 | 20 | 0.03 |
| Philadelphia Naming Test | 69.3 | 45.0 | 54.1 | 84.5 | 48.6 | 38 | 34.4 | 62.8 | 0.04 |
| PNT þ Naming 80 | 92.3 | 62.4 | 71.2 | 113.4 | 63.0 | 52.4 | 43.4 | 82.5 | 0.04 |
| PPTT Total Score | 46.6 | 3.4 | 45.4 | 47.7 | 46.1 | 4.6 | 44.4 | 47.8 | 0.65 |
| WAIS III Matrix Score | 12.4 | 5.8 | 10.5 | 14.4 | 11.6 | 4.9 | 9.7 | 13.4 | 0.63 |
| NIH Stroke Scale | 4.8 | 2.9 | 3.8 | 5.8 | 5.2 | 3.4 | 4 | 6.5 | 0.55 |
| Age | 61.9 | 9.2 | 58.8 | 65.0 | 57.3 | 11.1 | 53.2 | 61.5 | 0.07 |
| Years of Education | 14.8 | 2.1 | 14.1 | 15.5 | 14.9 | 2.8 | 13.9 | 16 | 0.74 |
| Time post stroke (months) | 50.3 | 42.8 | 35.9 | 64.8 | 35.5 | 38.9 | 21.0 | 50.0 | 0.16 |
| Lesion Size | 118.5 | 62.8 | 97.3 | 139.8 | 141.6 | 84 | 119 | 172 | 0.17 |
When adjusting for time post stroke and lesion size the main effect of BDNF genotype on WAB-R AQ and PNT+Naming 80 is no longer statistically significant (p = 0.11, p = 0.17, respectively).