Table 2:

Multivariable outcome models with clinical factors, HPV status, Worst Pattern of Invasion (WPOI) and SOX2 score

		OS				RFS
Parameter		HR	95% Hazard Ratio Confidence		p-value	HR	95% Hazard Ratio Confidence		p-value
Age	10 years	1.15	0.9	1.48	0.27	0.95	0.72	1.27	0.75
Stagea	1 (ref)
	2	1.31	0.3	5.8	0.72	0.67	0.09	4.93	0.7
	3	3.32	0.86	12.87	0.08	4.63	0.86	24.77	0.07
	4	2.45	0.7	8.58	0.16	3.1	0.64	14.87	0.16
Disease Site	Larynx (ref)
	Oral Cavity	1.72	0.79	3.78	0.17	1.4	0.54	3.64	0.49
	Oropharynx	3.29	1.15	9.4	0.03	5.16	1.61	16.59	0.006
	Hypopharynx	9.96	2.53	39.3	0.001	11.3	2.76	46.32	0.0008
HPV status	Negative (ref)
	Positive	0.3	0.11	0.78	0.01	0.14	0.04	0.42	0.0005
	invalid/missing	0.79	0.32	1.98	0.62	0.81	0.27	2.48	0.72
Comorbidities	none (ref)_
	mild	2.27	1.05	4.92	0.04	1.56	0.71	3.44	0.27
	moderate	1.3	0.47	3.61	0.61	0.88	0.29	2.68	0.83
	severe	4.57	1.61	12.96	0.004	3.39	1.13	10.16	0.03
Smoking	never (ref)
	current in past 12 mos	2.87	1.09	7.54	0.03	0.95	0.36	2.49	0.91
	former smoker > 12 mos	1.26	0.47	3.38	0.65	0.52	0.2	1.38	0.19
WPOI	1 (ref)
	2	1.41	0.38	5.3	0.61	0.76	0.23	2.54	0.66
	3	2.1	0.55	8.03	0.28	0.8	0.23	2.83	0.73
	4	1.5	0.36	6.31	0.58	0.73	0.2	2.7	0.64
SOX2 >1		0.48	0.26	0.89	0.02	0.4	0.21	0.76	0.005

^aAmerican Joint Committee on Cancer - 7.0 Edition; OS = Overall Survival, RFS = Recurrence Free Survival, HR = Hazard Ratio