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. 2019 Jan;71(1):1–19. doi: 10.1124/pr.118.016253

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Fig. 1. — Diagram illustrating development of structural genomics and cancer genomes. (A) Number of tumor genomes sequenced by The Cancer Genome Atlas across 26 major cancer types from Genomic Data Commons Data Portal (https://portal.gdc.cancer.gov). (B) Number of PDB structures of human proteins from 1988 to 2017 from PDB database (https://www.rcsb.org). (C) Genotyping by next-generation sequence technology. (D) Regulatory non-coding mutations in cancer. (E) Protein structural view of coding mutations in cancer.