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. 2018 Dec 10;13:8395–8410. doi: 10.2147/IJN.S188016

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© 2018 Shobaki et al. This work is published and licensed by Dove Medical Press Limited

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The relationship between lipid quantity and the pKa value of the LNP membrane.

Notes: (A) The relationship between the YSK12-C4 ratio in total lipids (X/70) and the pKa value for the YSK05/12-LNP membrane, theoretically simulated or experimentally measured using Equation 1 or TNS assay, respectively. (B) Determination of Y value (contribution factor) of YSK12-C4 lipid in the modified Equation 2.

Abbreviations: LNP, lipid nanoparticle; TNS, 6-(p-toluidino)-2-naphthalenesulfonic acid; pKa, acid dissociation constant.