Figure 1.

Effect of celastrol (Cel) on breast cancer-cell viability and xenograft growth.

Notes: MCF7 cells (A) and MDA-MB231 cells (B) were treated with different doses of Cel as indicated for 24 hours and 48 hours, respectively. Cell viability was measured by MTT assay. *P<0.05 vs control (Ctr) at 24 h. **P<0.01 vs Ctr at 24 h. ^##P<0.01 vs Ctr at 48 h. (C) Tumor-growth curves of xenografts derived from MDA-MB231 cells with or without Cel treatment. **P<0.01. (D) Histochemical staining of Ki67 in the xenografts with or without Cel treatment. Representative images shown.