Figure 3.

ACTIVIN + Dasatinib (YAP1i)-Derived PS Cells Differentiate into Endoderm and Cardiac Lineages

(A) The diagram illustrates the different procedures that were tested for hESC differentiation.

(B) mRNA abundance of MEOX1, NKX2.5, and SOX17 on day 5 from the initial treatments in H1 hESCs, as indicated in diagram. n = 3 biological independent experiments, mean ± SD. ^∗p < 0.05; ^∗∗∗p < 0.001.

(C) The diagram illustrates the various signaling cues that direct PS fate specification to mesendodermal lineages.