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. Author manuscript; available in PMC: 2020 Jan 15.
Published in final edited form as: Coord Chem Rev. 2017 Sep 22;379:99–120. doi: 10.1016/j.ccr.2017.09.002

Figure 11.

Figure 11

64Cu-porphysomes as a PET agent. A) Schematic diagram of the multimodal properties of 64Cu-porphysomes as a result of directly radiolabeling a fraction of the porphyrin-lipid bilayer of preformed photonic porphysomes creating intrinsic multimodal nanoparticles. 64Cu-porphysome selectivity in orthotopic prostate tumor models. Representative MicroPET/CT images of (i) axial, (ii) coronal, and (iii) sagittal single slices through (B) orthotopic PC3 tumor (n = 8), (C) orthotopic 22RV1 tumor (n = 3), and (D) healthy male mice (n = 3) at 24 h after intravenous injection of 500μL Ci 64Cu-porphysomes: PET image integration time 40 min. White arrows depict prostate tumor; blue arrows depict bladder. Permission obtained from Ref.[113]. Copyright (2013) by American Chemical Society.