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. 2018 Apr 11;2(3):031902. doi: 10.1063/1.5022595

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© 2018 Author(s).

2473-2877/2018/2(3)/031902/15

All article content, except where otherwise noted, is licensed under a Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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FIG. 4. — (a) Collagen Specific Second Harmonic Generation image of collagen at the CIC boundary (Scale bar = 20 μm). (b) CT-FIRE identification of collagen fibers. (c) CurveAlign image identifying the angle and distance from the boundary for each fiber. [(d)–(e)] Collagen fibers at the CIC boundary were significantly more aligned to the boundary compared to stromal fibers in both benign (n = 10) and HGSOC (n = 13) patients. Data are an average of the alignment percentages found in each CIC, n = 904–6544 fibers per CIC, and p < 0.001 between the CIC boundary and bulk by a two-sided t-test.