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[(a) and (b)] Increasing collagen density decreased the number of cells that invaded and the distance of invasion. n = 12–43 lumens per condition, different letters indicate significantly different groups by Tukey-HSD, and p < 0.01. [(c), (d)] Incorporating collagen III increased the number of cells that invaded but did not impact the invasion distance. n = 17–19 lumens per condition; * indicates p < 0.001 by the two-sided t-test.
