Fig. 6. p62 mediates oxidative stress-induced parthanatos.
a, b HT1080 cells were treated with the indicated concentrations of H2O2 for 5 h, and then subjected to cell viability assay. Data shown are the mean ± SD. Significant differences were determined by one-way ANOVA, followed by Tukey–Kramer test; ***p < 0.001; **p < 0.01; *p < 0.05. c HT1080 cells were treated with 0.4 mM H2O2 for the indicated periods, and then the nuclear and cytoplasmic extracts were subjected to immunoblotting with the indicated antibodies