Fig. 7.

IL-6 mediates vagal signal-induced hepatic FoxM1 activation. a Relative expressions of Foxm1, its target genes, and MKi67 in primary hepatocytes isolated from control and iFoxM1LKO mice treated with 100 ng/ml IL-6 (n = 7–8 per group) and vehicle (n = 7–8 per group) for 6 h. b (Left panels) Representative images of liver extract immunoblottings with anti-phospho-STAT3, total STAT3, and actin. (Right panel) Relative intensities of phospho/total STAT3 in livers from sham operation for PHx (SO)- (n = 6), PHx-sham- (n = 6), and PHx-HV mice (n = 6). c Relative expressions of Foxm1, its target genes, and MKi67 in the liver 2 days after surgery from SO + IgG (n = 5), PHx + IgG (n = 5), and PHx + anti-IL-6 antibody- (n = 5) treated mice. Data are presented as means ± SEM. *P < 0.05; **P < 0.01 assessed by unpaired t test (a), or assessed by one-way ANOVA followed by Bonferroni’s post hoc test (b and c). n.s., not significant