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. 2018 Dec 14;9:5331. doi: 10.1038/s41467-018-07580-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — PCF11 is a key driver of TREND in neuroblastoma with a potential role in neurodifferentiation. a Protein profiling of BE(2)-C cells by western blotting (Supplementary Figure 4) reveals downregulation of PCF11 during ATRA-induced neuroblastoma differentiation (highlighted are the top three TREND-regulators; y-axis, fold-change protein abundance; x-axis, percentage of TREND-affected genes; mean ± s.e.m., two independent replicates; inlet shows a representative PCF11 western blot with equal loading). b PCF11 depletion regulates TREND of target genes with a role in neuronal differentiation (GO enrichment analysis of TREND-affected target genes with a protein change upon PCF11 depletion (obtained by differential mass spectrometry of BE(2)-C cells with and without depletion of PCF11) Supplementary Table 4)